文献类型     学术论文
标    题     Interferon stimulates cholesterol and phosphatidylcholine synthesis but inhibits cholesterol ester synthesis in HeLa-S3 cells
著    者     LAWRENCE M. PFEFFER; BILL C. P. KWOK; FRANK R. LANDSBERGER; IGOR TAMM
机    构     The Rockefeller University
集合名     Proc. Nati. Acad. Sci. USA
年 1985
月 4
卷 82
地    域     New York, NY
文件大小     1020.77 KB
描    述     Treatment of human HeLa-S3 cells (an epi- dermoid carcinoma line) with human (-interferon (640 units/ ml) selectively alters lipid metabolism by increasing cholesterol synthesis per mg of cell protein as measured by 1-hr pulse- labeling of cells with [3H]acetate. Cholesterol synthesis in in- terferon-treated cells is increased -60% at 24 hr after the be- ginning of treatment and -450% at 48 hr. Continuous label- ing of interferon-treated cells with [14C]acetate shows increased accumulation of la...More

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