文献类型     学术论文     
标    题     Early termination of heterogeneous nuclear RNA transcripts in mammalian cells: Accentuation by 5,6-dichloro-1- f3-D-ribofuranosylbenzimidazole
著    者     IGOR TAMM; TOYOKO KIKUCHI
机    构     The Rockefeller University
主题词     nuclear RNA-synthesizing system; HeLa cells; RNA polymerase II; kinetics of chain elongation; heparin
集合名     Proc. Natl. Acad. Sci. USA
年 1979
月 11
卷 76
期 11
地    域     New York
文件大小     1.51 MB     
描    述     Labeling of RNA in isolated HeLa cell nuclei in vitro reveals an abundance of short RNA chains made by RNA polymerase II. Thesi short chains were initiated prior to isolation of the nuclei. The'hort abundant chains are increased in amount in nuclei isola d from cells treated with 5,6-di- chlorol-t-o-ribofuranosylb nzimidazole (DRB). Kinetic evi- dence indicates that the bulk of the putative heterogeneous nuclear RNA (hnRNA) precur.r molecules that are terminated early in vivo are terminated 4100...More

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