文献类型     学术论文
标    题     DNA REPLICATION : DIRECTION AND RATE OF CHAIN GROWTH IN MAMMALIAN CELLS
著    者     ROGER HAND; IGOR TAMM
机    构     The Rockefeller University; Departments of Medicine and Microbiology, McGill University
系列号     PISSN 0021-9525; EISSN 1540-8140
集合名     THE JOURNAL OF CELL BIOLOGY
发布机构     rockefeller university press.
年 1973
月 8
卷 58
地    域     Quebec, Canada
文件大小     679.48 KB
描    述     Using pulse labeling techniques with [3H]thymidine or [3H]cytidine, combined with DNA fiber autoradiography, we have investigated the direction and rate of DNA chain growth in mammalian cells. In general, chain elongation proceeds bidirectionally from the common origin of pairs of adjacent replication sections . This type of replication is noted whether the DNA is labeled first with [3H]thymidine of high specific activity, followed by [ 3H]thymi- dine of low specific activity or the sequence is ...More

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